Potential effects of lowering the threshold of statistical significance in the field of chronic rhinosinusitis - A meta-research on published randomized controlled trials over last decade

Abstract Objective: To evaluate the impact of change in p-value threshold from 0.05 to 0.005, on published Randomized Controlled Trials (RCTs) over the last ten years in the field of chronic rhinosinusitis. Methods: A search of the PubMed database from 1st January 2011 to 31st December 2020 was conducted to include all RCTs that used p-value to determine the effects of an intervention. Data extracted included p-values, type of intervention, publishing journal with indexing, registration, funding, and multi- or single center status. The proportion of primary endpoints having p < 0.005 was determined first, followed by those with p > 0.005 but <0.05. Logistic regression analysis was used to determine if any trial characteristic was associated with reporting of significant p-values. Results: In total, 168 primary endpoints were identified from 123 RCTs. On analysis, 80 had a p-value <0.05, i.e., statistically significant on conventional parameter. Out of these, 53.75% had a p-value <0.005, which would retain significance under the proposed threshold, and the remaining 46.25% to be reclassified as ''suggestive''. None of the trial characteristics were contributing to reporting of conventional or proposed p-values on logistic regression analysis. Conclusion: Lowering the p-value threshold would render 46.25% of a decade of published RCTs results (in the field of CRS) to be reclassified as merely ''suggestive'' and not significant. Trial characteristics were not found contributing to reporting of p-value <0.005 or even <0.05. Level of evidence: II.

Publications analysis of major medical institutions in China indexed in PubMed from 2019 to 2021 / 中华医学科研管理杂志

Objective:To understand the development trend of scientific research in major medical institutions in China from 2019 to 2021.Methods:The PubMedplus database was searched, and the distribution of papers, published journals and its′ influencing factors (IF) of top 30 domestic medical institutions from 2019 to 2021 were statistically analyzed.Results:From 2019 to 2021, 84 405 PubMed papers were published by the top 30 medical institutions, including 79 459 papers in English, accounted for 94.14%, and 4 946 papers in Chinese, accounted for 5.86%. Of them, 22 447, 29 540 and 32 430 papers were published in 2019, 2020 and 2021. 75 240 papers in English were indexed by SCI database (89.14% of total English papers). 17 729 papers (accounted for 21.00%) were published by the top 27 journals, Frontier in Oncology ranks first. 4 400 papers (5.85% of total) were published by the journals of impact factors greater than 10. The biggest portion of the papers, 26 550 papers (35.29% of total) were published by the journals of impactor factor from 3 to 5. Conclusions:The quantity and quality of papers published by major medical institutions in China have been greatly improved each year. The progress level of medical institutions is different, and their advantageous disciplines of medical institutions have been well reflected.

Transcanalicular laser dacryocystorhinostomy with and without mitomycin / 国际眼科杂志(Guoji Yanke Zazhi)

@#AIM: To investigate if mitomycin reduces or not the probability of developing synechiae and granulomas in transcanalicular diode laser dacryocystorhinostomy. Also, we want to clarify the usefulness of mitomycin in that procedure by searching in PubMed between 2011 and 2021. <p>METHODS: A retrospective case series study of 120 transcanalicular diode laser dacryocystorhinostomy was performed from January 2008 to July 2019. Patients were divided into two groups: one group was operated on with mitomycin and the other group was operated on without mitomycin.<p>RESULTS: The success rate was 71.9% in the mitomycin group and 71.0% in the non- mitomycin group.<p>CONCLUSION: No statistically significant differences in the outcomes of the two groups were found. Only two opposing articles regarding the use of mitomycin in transcanalicular diode laser dacryocystorhinostomy were found in PubMed between 2011 and 2021, so the use of mitomycin is still unclear.

Avances de la bioinformática en Costa Rica: vista retrospectiva y perspectivas / Bioinformatics advances in Costa Rica: retrospective view and perspectives

Resumen Introducción: La disciplina científica de la bioinformática tiene el potencial de generar aplicaciones innovadoras para las sociedades humanas. Costa Rica, pequeña en tamaño y población en comparación con otros países de América Latina, ha ido adoptando la disciplina de manera progresiva. El reconocer los avances permite determinar hacia dónde puede dirigirse el país en este campo, así como su contribución a la región latinoamericana. Objetivo: En este manuscrito se reporta evidencia de la evolución de la bioinformática en Costa Rica, para identificar debilidades y fortalezas que permitan definir acciones a futuro. Métodos: Se realizaron búsquedas en bases de datos de publicaciones científicas y repositorios de secuencias, así como información de actividades de capacitación, redes, infraestructura, páginas web y fuentes de financiamiento. Resultados: Se observan avances importantes desde el 2010, incluyendo un aumento en oportunidades de entrenamiento y número de publicaciones, aportes significativos a las bases de datos de secuencias y conexiones por medio de redes. Sin embargo, ciertas áreas, como la masa crítica y la financiación requieren más desarrollo. La comunidad científica y sus patrocinadores deben promover la investigación basada en bioinformática, invertir en la formación de estudiantes de posgrado, aumentar la formación de profesionales, crear oportunidades laborales para carreras en bioinformática y promover colaboraciones internacionales a través de redes. Conclusiones: Se sugiere que para experimentar los beneficios de las aplicaciones de la bioinformática se deben fortalecer tres aspectos clave: la comunidad científica, la infraestructura de investigación y las oportunidades de financiamiento. El impacto de tal inversión sería el desarrollo de proyectos ambiciosos pero factibles y colaboraciones extendidas dentro de la región latinoamericana. Esto permitiría realizar contribuciones significativas para abordar los desafíos globales y la aplicación de nuevos enfoques de investigación, innovación y transferencia de conocimiento para el desarrollo de la economía, dentro de un marco de ética de la investigación.

Abstract Introduction: The scientific discipline of bioinformatics has the potential to generate innovative applications for human societies. Costa Rica, small in size and population compared to other Latin American countries, has been progressively adopting the discipline. Recognizing progress makes it possible to determine where the country can go in this field, as well as its contribution to the Latin American region. Objective: This manuscript reports evidence of the evolution of bioinformatics in Costa Rica, to identify weaknesses and strengths allowing future actions plans. Methods: We searched databases of scientific publications and sequence repositories, as well as information on training activities, networks, infrastructure, web pages and funding sources. Results: Important advances have been observed since 2010, such as increases in training opportunities and the number of publications, significant contributions to the sequence databases and connections through networks. However, areas such as critical mass and financing require further development. The scientific community and its sponsors should promote bioinformatics-based research, invest in graduate student training, increase professional training, create career opportunities in bioinformatics, and promote international collaborations through networks. Conclusions: It is suggested that in order to experience the benefits of bioinformatics applications, three key aspects must be strengthened: the scientific community, the research infrastructure, and funding opportunities. The impact of such investment would be the development of ambitious but feasible projects and extended collaborations within the Latin American region and abroad. This would allow significant contributions to address global challenges and the implementation of new approaches to research, innovation and knowledge transfer for the development of the economy, within an ethics of research framework.

Cardiothoracic Surgery in the Caribbean

Abstract Introduction: Despite being one of the main vacation destinations in the world, health care in the Caribbean faces many difficulties. The challenges involved in these islands' medical care range from low-resource institutions to lack of specialized care. In the field of thoracic and cardiac surgery, many limitations exist, and these include the lack of access to cardiac surgery for many small islands and little governmental funding for minimally invasive approaches in thoracic surgery. Methods: Literature review was done using PubMed/MEDLINE and Google Scholar databases to identify articles describing the characteristics of thoracic and cardiac surgery departments on Caribbean islands. Articles on the history, current states of practice, and advances in cardiothoracic surgery in the Caribbean were reviewed. Results: Regardless of the middle to high-income profile of the Caribbean, there are significant differences in the speed of technological growth in cardiothoracic surgery from island to island, as well as disparities between the quality of care and resources. Many islands struggle to advance the field of cardiothoracic surgery both through lack of local cardiac surgery centers and limited financial funding for minimally invasive thoracic surgery. Conclusions: Cardiac and thoracic surgery in the Caribbean depend not only on the support from local government policies and proper distribution of healthcare budgets, but efforts by the surgeons themselves to change and improve institutional cultures. Although resource availability still remains a challenge, the Caribbean remains an important region that deserves special attention with regard to the unmet needs for long-term sustainability of chest surgery.

Análisis temático desde el Observatorio Métrico de Coronavirus de las investigaciones publicadas en PubMed / Thematic analysis from the Coronavirus Metric Observatory of the research published in PubMed

La experiencia científica de los últimos meses contra la pandemia de la COVID-19 muestra una celeridad nunca vista, así mismo, es inédita la velocidad en la publicación de los resultados de tales investigaciones. El contexto revela la carrera sostenida que tiene la ciencia contra la expansión de este letal virus. En el presente estudio se documentan evidencias bibliográficas para reconocer a PubMed como uno de los principales recursos de información científica sobre medicina que existen en el mundo. Es una necesidad del gremio científico médico e investigativo en el contexto de la COVID-19 conocer las temáticas que abordan los principales artículos de la base de datos. El objetivo de esta investigación es analizar el comportamiento temático de los artículos publicados por PubMed sobre coronavirus en el primer semestre del año 2020 utilizando como herramienta de análisis al Observatorio Métrico de Coronavirus de la Universidad de Pinar del Río. El interés científico del estudio se concentra en las variables materia, MeSH y palabras clave; las que son analizadas con diferentes técnicas métricas que facilitan la visualización e interpretación de los resultados. Se demostró que PubMed, entre los temas más recurrentes, ha socializado investigaciones en virología, microbiología, farmacéutica, medicina general integral y sus relaciones con la oncología, neurología, pediatría, psicología, psiquiatría, oftalmología, nutrición, telemedicina y dispositivos médicos(AU)

The scientific experience of recent months against the COVID-19 pandemic shows a speed never seen before, likewise, the speed in the publication of the results of such investigations is unprecedented. The context reveals the sustained race in science against the spread of this deadly virus. In this study, bibliographic evidence is documented to recognize PubMed as one of the main sources of scientific information on medicine that exist in the world. In the context of COVID-19, it is a necessity for the scientific, medical and research union to know the issues addressed by the main articles in the database. The objective of this research is to analyze the thematic behavior of the articles published by PubMed on coronavirus in the first half of 2020, using the Coronavirus Metric Observatory of the University of Pinar del Río as an analysis tool. The scientific interest of the study is concentrated in the variables subject, MeSH and keywords; those that are analyzed with different metric techniques that facilitate the visualization and interpretation of the results. It was shown that PubMed, among the most recurrent topics, has socialized research in virology, microbiology, pharmaceuticals, comprehensive general medicine and their relationships with oncology, neurology, pediatrics, psychology, psychiatry, ophthalmology, nutrition, telemedicine and medical devices(AU)

Analysis of Characteristics of Clinical Researches on Sacral Nerve Stimulation Based on PubMed Database / 中国康复理论与实践

Objective:To analyze the clinical studies on sacral nerve stimulation based on PubMed database and summarize its research status and clinical characteristics. Methods:Literatures about sacral nerve stimulation were collected from PubMed database before December 31, 2019. HistCite software was used to analyze the published year, published periodicals, published country and research institutions. Pajek software principal path analysis was used to identify the evolution direction of hot topics. The spectrum of diseases, therapeutic outcomes, stimulation methods and stimulation parameters were summarized. Results:A total of 96 articles were included. The number of publications increased significantly since 2000 and reached its peak in 2014 to 2015. The literatures with most influence were published in 2000 to 2001. All the literatures published in 32 journals, the top two were Urology and Diseases of the Colon & Rectum, which published 17 and 22 articles, respectively. The literatures came from 16 countries, and the top three were the United State (17 articles), the Netherlands (13) and the United Kingdom (13). Among the 211 institutes involved, Aarhus University Hospital (Denmark, twelve articles) and St. Marks Hospital (United Kingdom, nine) were the top two. The study involved 16 diseases, mainly about fecal incontinence, urinary incontinence and urination, shifted from urinary system diseases to digestive system diseases. 91.67% of the study corroborated the benefit of sacral nerve stimulation. Implanted stimulation (77 articles) was the most used, and transdermal stimulation (10 articles) was the second. The parameters were depending on the disease and the mode of stimulation. Conclusion:Sacral nerve stimulation can effectively improve the function of pelvic floor, which may be focused for a long time. Non-implantable sacral nerve stimulation would become the new research topic.

The current management of cardiac tumours: a comprehensive literature review

Abstract Objective: To understand the current evidence and guidelines behind the appropriate management of cardiac tumours. Methods: A comprehensive electronic literature search has been performed in major databases - PubMed, Embase, Scopus, Ovid, and Google Scholar. All articles that discussed all different forms of cardiac tumours, their clinical presentation, diagnosis, and management methods have been critically appraised in this narrative review. Results: All relevant studies have been summarized in appropriate sections within our review. Cardiac tumours are rare but can be catastrophic and life-threatening if not identified and managed on timely manner. Utilization of all the available imaging methods can be of equivocal importance, relevant to each cardiac tumour. Surgical excision is the ultimate treatment method, however histopathological results can guide the adjunct treatment. Conclusion: Early detection of cardiac tumours has significant effect on planning the method of intervention. Technological advancements and increased availability of imaging modalities have enabled earlier and more accurate detection of these tumours. Novel medical therapies, recommendations for screening, and operative techniques have all contributed to overall improving knowledge of these tumours and ultimately patient outcomes.

Estilos de vida en profesionales de salud de un hospital en Chiclayo, Perú 2017 / Lifestyles in health professionals of a hospital in Chiclayo, Peru 2017

RESUMEN Introducción: Alrededor del 75 por ciento de las enfermedades no transmisibles y el 40 por ciento de cáncer pueden prevenirse si los factores de riesgo como los malos estilos de vida, inactividad física y consumo de sustancias nocivas pudieran eliminarse. Los profesionales de salud deberían realizar y hacer recomendaciones a los pacientes sobre los estilos de vida saludables. Objetivos: Determinar los factores asociados a los estilos de vida no saludables de los profesionales de la salud en un hospital de Chiclayo. Material y Métodos: Se realizó un estudio descriptivo transversal en profesionales de la salud del Hospital Naylamp-Chiclayo en el año 2017. Se aplicó el cuestionario adaptado de prácticas y creencias sobre estilos de vida, el cuestionario medía variables sociodemográficas, estado nutricional y prácticas saludables (actividad física, hábitos alimenticios, consumo de tabaco y alcohol); las respuestas fueron clasificadas en saludables y no saludables. Se aplicó la prueba de chi cuadrado para asociar estilos de vida y sus factores asociados. Resultados: De los encuestados, 44,6 por ciento tenían sobrepeso y obesidad. La categoría de los estilos de vida que predominó fue no saludable con 58,7 por ciento. Las categorías que predominaron fueron: hábitos alimentarios poco saludables con 52,1 por ciento, hábito de fumar (pasivo/activo) con 58,7 por ciento. Se encontró asociación entre edad joven, sexo femenino, sobrepeso u obesidad, ser profesional no médico y ser fumador con los estilos de vida no saludables. Conclusiones: Existe personal de salud con baja actividad física, consumo de tabaco, mala alimentación. Se concluye que los estilos de vida son poco saludables en los profesionales de la salud en Chiclayo(AU)

ABSTRACT Introduction: About 75 percent of noncommunicable diseases and 40 percent of cancers can be prevented if risk factors such as poor lifestyles, physical inactivity and substance abuse are eliminated. Health professionals should make recommendations to patients about healthy lifestyles. Objective: To determine the factors associated with unhealthy lifestyles in health professionals of a hospital in Chiclayo. Material and Methods: A cross-sectional descriptive study was conducted in health professionals at the Naylamp-Chiclayo Hospital in 2017. The adapted questionnaire of practices and beliefs about lifestyles was applied; the questionnaire measured sociodemographic variables, nutritional status and healthy practices (physical activity, eating habits, tobacco and alcohol consumption); the answers were classified as healthy and unhealthy. The Chi-square test was used to establish an association between lifestyles and their related factors. Results: Of the respondents, 44.6 percent were overweight and obese. The predominant lifestyle category was unhealthy lifestyle (58.7 percent). The predominant categories were: unhealthy eating habits (52.1 percent), smoking (passive/active) (58.7 percent). Associations were found between young age, female sex, overweight or obesity, and being a non-medical professional and a smoker with unhealthy lifestyles. Conclusions: Low physical activity, tobacco consumption, and poor diet have been identified in health professionals. It is concluded that health professionals in Chiclayo have unhealthy lifestyles(AU)

Contribuições técnicas e socioculturais da prevenção quaternária para a atenção primária à saúde: caminhos e desafios / Technical and socio-cultural contributions of quaternary prevention for primary health care: paths and challenges / Contribuciones técnicas y socioculturales de prevención cuaternaria para la atención primaria de salud: caminos y desafíos

Introdução: No contexto do Sistema Único de Saúde, o conceito da prevenção quaternária adentra timidamente os níveis de atenção à saúde, no entanto, sofre expansão significativa no âmbito da atenção primária à saúde. Objetivo: Identificar por meio da sistematização de evidências científicas, as contribuições técnicas e socioculturais da prevenção quaternária no âmbito da atenção primária à saúde no Brasil. Métodos: Trata-se de uma revisão integrativa de estudos presentes nas bases de dados científicas da Scientific Electronic Library Online, Biblioteca Virtual em Saúde, biblioteca virtual da Comissão de Aperfeiçoamento de Pessoal do Nível Superior e MEDLINE via PubMed com a utilização dos descritores "prevenção quaternária" e "atenção primária à saúde", em inglês e português. Resultados: O corpus de análise foi composto por 22 artigos, sendo que a produção científica sobre o tema se deu de forma mais intensa a partir do ano de 2015 e, em sua maioria, possuíam como abordagem metodológica ensaios teóricos. Dentre as contribuições técnicas destacaram-se a introdução do ensino da prevenção quaternária de modo continuado aos graduandos e profissionais; a construção de protocolos e documentos de amparo profissional; a utilização de modelos explicativos dinâmicos na socialização do quadro clínico; a conduta profissional com os usuários e as contribuições socioculturais envolvendo mudanças na percepção profissional e comunitária sobre o fenômeno saúde-doença, assim como o incentivo a práticas de desmedicalização sociocultural em relação à dor, incapacidade, desconforto, envelhecimento, nascimento e morte. Conclusão: Apesar do reconhecimento das potencialidades da prevenção quaternária, faz-se necessário fortalecer estratégias que possibilitem o desenvolvimento de políticas públicas para fomentar e gerenciar alianças estratégicas com tomadores de decisão, profissionais de saúde e cidadãos, para fomentar a redução de diagnósticos e tratamentos excessivos, contribuindo com a qualidade do cuidado.

Introduction: In the context of the Unified Health System, the concept of quaternary prevention shyly enters the levels of health care, however, undergoes significant expansion in the scope of primary health care. Objective: To identify, through the systematization of scientific evidence, the technical and socio-cultural contributions of quaternary prevention within the scope of primary health care in Brazil. Methods: This is an integrative review of studies present in the scientific databases of the Scientific Electronic Library Online, Regional Portal of the Virtual Health Library of the Latin American and Caribbean Center on Health Sciences Information of the Pan American Health Organization, virtual library of the Higher Education Personnel Improvement Commission, and MEDLINE through PubMed using the descriptors "quaternary prevention" and "primary health care", in English and Portuguese. Results: The corpus of analysis consisted of 22 articles, and the scientific production on the topic took place more intensively from the year 2015 and, for the most part, had theoretical essays as methodological approach. Among the technical contributions, we highlight the introduction of teaching on quaternary prevention in a continuous way to undergraduates and professionals; the construction of protocols and documents of professional support; the use of dynamic explanatory models in the socialization of the clinical picture and professional conduct with users and socio-cultural contributions involve changes in the professional and community perception about the phenomenon of illness and health conception, as well as the incentive to practices of socio-cultural demedicalization in relation to pain, disability, discomfort, aging, birth, and death. Conclusion: Despite the recognition of the potential of quaternary prevention, it is necessary to strengthen strategies that enable the development of public policies to foster and manage strategic alliances with decision makers, health professionals and citizens, to promote the reduction of excessive diagnoses and treatments, contributing to the quality of care.

Introducción: En el contexto del Sistema Único de Salud, el concepto de prevención cuaternaria entra tímidamente en los niveles de atención de salud, sin embargo, experimenta una expansión significativa en el alcance de la Atención Primaria de Salud. Objetivo: Identificar, a través de la sistematización de evidencia científica, las contribuciones técnicas y socioculturales de la prevención cuaternaria en el ámbito de la Atención Primaria de Salud en Brasil. Métodos: Esta es una revisión integradora de estudios presentes en las bases de datos científicas de la Biblioteca Electrónica Científica en línea, Portal Regional de la Biblioteca Virtual en Salud del Centro Latinoamericano y del Caribe de Información en Ciencias de la Salud de la Organización Panamericana de la Salud, biblioteca virtual de la Comisión de Mejoramiento del Personal de Educación Superior y MEDLINE a través de PubMed utilizando los descriptores de prevención cuaternaria y atención primaria de salud, en inglés y portugués. Resultados: El corpus de análisis estuvo conformado por 22 artículos, siendo la producción científica sobre el tema más intensiva desde 2015 y, en su mayor parte, tuvo ensayos teóricos como abordaje metodológico. Entre los aportes técnicos, destacamos la implantación de la docencia en prevención cuaternaria de forma continua a estudiantes de pregrado y profesionales; construcción de protocolos y documentos de apoyo profesional, uso de modelos explicativos dinámicos en la socialización del cuadro clínico y conducta profesional con los usuarios y los aportes socioculturales implican cambios en la percepción profesional y comunitaria sobre el fenómeno de la enfermedad y la concepción de la salud, así como el incentivo a prácticas de desmedicalización sociocultural en relación al dolor, discapacidad, malestar, envejecimiento, nacimiento y muerte. Conclusión: A pesar del reconocimiento del potencial de la prevención cuaternaria, es necesario fortalecer estrategias que permitan el desarrollo de políticas públicas para fomentar y gestionar alianzas estratégicas con los tomadores de decisiones, profesionales de la salud y ciudadanos, para promover la reducción de diagnósticos y tratamientos excesivos, contribuyendo a la calidad de la atención.

Ranking analysis of the PubMed publications from major Chinese medical institutions in 2018 / 中华医学科研管理杂志

Objective To study the overall distribution of the PubMed papers published by major Chinese medical institutions in 2018.Methods We collected all the publications from PubMed database published by major Chinese medical institutions in 2018.Indicators includ the distribution of the number of papers,publication type,journal's impact factor and disciplines of source journals were analyzed.Results 18 057 PubMed papers were published by the top 30 Chinese medical institutions,among which 16 744 (92.73％) were in English,1313(7.27％) in Chinese.2 286 (12.66％) papers were Published by top 14 journals,and the Medicine hold the top on source journal ranking.The impact factor of source journals of 236 papers(1.51 ％) were over 10,and 4827 papers (30.84％) were among 2-3.Besides,tumor subject papers accounted a higher proportion.Conclusions The number of published papers by major Chinese medical institutions was increasing,the quality of journals published was improved even though the lack of high-quality journals.The disciplinary distribution in different medical institutes were concentrated.

Use of Social Networks for Data Collection in Scientific Productions in the Health Area: Integrative Literature Review / Uso de redes sociales para recolección de datos en producciones científicas en el área de la salud: revisión integrativa de la literatura / Utilização de redes sociais para coleta de dados em produções científicas na área da saúde: revisão integrativa da literatura

ABSTRACT Objective: To investigate evidence on the use of social networks to collect data in scientific productions in the health area. Material and method: An integrative literature review from primary studies indexed in the SciELO, PubMed, LILACS, Scopus, and Web of Science platforms. Results: 16 scientific articles were selected, of which nine focused on the use of WhatsApp; five, on the use of Facebook; and two, on employing Twitter to collect data in scientific productions. Growth was noted on the number of investigations associated to the use of social networks, although an important paradigm still exists related to the use to generate scientific evidence, resulting in a still low number of investigations on this theme. Conclusions: The health area needs to approach evermore the development of research associated to social networks, given that this would enable a viable and rapid intervention in obtaining responses, besides being a low cost and very promising tool for data collection.

RESUMEN Objetivo: investigar las evidencias del uso de redes sociales para recolectar datos en producciones científicas en el área de salud. Material y método: una revisión integrativa de la literatura a partir de estudios primarios indexados en las plataformas SciELO, PubMed, LILACS, Scopus y Web of Science. Resultados: se seleccionaron 16 artículos científicos, de los cuales nueve se centraron en el uso de WhatsApp; cinco, en el uso de Facebook; y dos, en empleo de Twitter para recolectar datos en producciones científicas. Hubo crecimiento en el número de investigaciones asociadas al uso de redes sociales, aunque aún existe un gran paradigma relacionado a su uso para generar evidencia científica, lo que resulta en un número aún reducido de investigaciones en esta temática. Conclusiones: el área de la salud necesita acercarse cada vez más al desarrollo de investigaciones asociadas a las redes sociales, pues esto posibilitaría una intervención viable y rápida en la obtención de respuestas, además de ser una herramienta de bajo costo y bastante promisoria para la recolección de datos.

RESUMO Objetivo: investigar as evidências da utilização de redes sociais para coleta de dados em produções científicas na área da saúde. Material e método: uma revisão integrativa da literatura a partir de estudos primários indexados nas plataformas SciELO, PubMed, LILACS, Scopus e Web of Science. Resultados: foram selecionados 16 artigos científicos, dos quais nove apresentaram foco na utilização do WhatsApp; cinco, no uso do Facebook; e dois, no emprego do Twitter para coleta de dados em produções científicas. Houve um crescimento no número de pesquisas associadas à utilização de redes sociais, embora ainda exista um grande paradigma relacionado ao uso para a geração de evidências científicas, o que resulta em um número ainda reduzido de pesquisas nessa temática. Conclusões: a área da saúde precisa aproximar-se cada vez mais do desenvolvimento de pesquisas associadas às redes sociais, pois isso possibilitaria uma intervenção viável e rápida na obtenção de respostas, além de ser uma ferramenta de baixo custo e bastante promissora para a coleta de dados.

Open Access Publishing in India: Coverage, Relevance, and Future Perspectives

Open access (OA) publishing is a recent phenomenon in scientific publishing, enabling free access to knowledge worldwide. In the Indian context, OA to science has been facilitated by government-funded repositories of student and doctoral theses, and many Indian society journals are published with platinum OA. The proportion of OA publications from India is significant in a global context, and Indian journals are increasingly available on OA repositories such as Pubmed Central, and Directory of Open Access Journals. However, OA in India faces numerous challenges, including low-quality or predatory OA journals, and the paucity of funds to afford gold OA publication charges. There is a need to increase awareness amongst Indian academics regarding publication practices, including OA, and its potential benefits, and utilize this modality of publication whenever feasible, as in publicly-funded research, or when platinum OA is available, while avoiding falling prey to poor quality OA journals.

Association of Interleukin-10 -1082A>G (rs1800896) Polymorphism with Predisposition to Breast Cancer: a Meta-Analysis based on 17 Case-Control Studies

SUMMARY INTRODUCTION The association between the between IL-10 -1082A>G (rs1800896) polymorphism and breast cancer has been evaluated by several number case-control studies. However, these studies might be underpowered to reveal the true association. OBJECTIVE We have performed a comprehensive meta-analysis to investigate the association IL-10 -1082A>G polymorphism and breast cancer. MATERIALS AND METHODS A systematic literature search was conducted using PubMed, Google Scholar, and Web of Science up to September 20, 2017. Data was analysed with CMA software to identify the strength of the association by pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs). RESULTS A total of 17 case-control studies involving 3275 cases and 3416 controls obtained from database searches were examined. Overall, there was no significant association between IL-10 -1082A>G polymorphism and breast cancer risk under all genetic models. No significant publication bias was found for the five genetic models (G vs. A OR = 1.184, 95% CI = 0.895-1.180, p= 0.230; GG vs. AA: OR = 1.430, 95% CI = 0.927-2.204, p= 0.106; GA vs. AA: OR = 0.966, 95% CI = 0.765-1.221, p= 0.774; GG+GA vs. AA: OR = 0.957, 95% CI = 0.697-1.314, p= 0.786; and GG vs. GA+AA: OR = 1.221, 95% CI = 0.981-1.518, p= 0.073). Moreover, there was no significant association between the IL-10 -1082A>G polymorphism and breast cancer risk by ethnicity. CONCLUSION Our findings indicated that IL-10 -1082A>G (rs1800896) polymorphism might not be a risk factor for the development of breast cancer.

RESUMO

Analysis on Randomized Controlled Trials for Acupuncture Treatment of Simple Obesity Collected from PubMed / 针刺研究

OBJECTIVE: To analyze studies published in journals included in PubMed in terms of randomized controlled trials (RCTs) examining the therapeutic effect of acupuncture for simple obesity, so as to provide a reference for subsequent RCT-related designs and results. METHODS: RCT literature about acupuncture treatment of simple obesity from the PubMed database and from 2000 to 2016 was retrieved by using keywords of "obesity" "fat" "acupuncture" "joint application of acupuncture and herbal medicine" or "auricular point" "electroacupuncture", "acupoint application", or "cupping", followed by screening, extraction and evaluation of the design methodology and outcomes using Consolidated Standards for Reporting of Trials (CONSORT) and Standards for Reporting Interventions in Controlled Trials of Acupuncture (STRICTA). RESULTS: Fourteen articles from six countries in Asia examining the therapeutic effect of acupuncture in the treatment of simple obesity mainly by using acupoints of the Stomach Meridian were included. Generally, acupuncture was found to be more effective than sham acupuncture. However, PubMed did not include any RCTs comparing acupuncture with western medicine for weight loss and many problems (as details of needling manipulation, etc.) remained in the the research reports available in the database. CONCLUSION: All the existing RCTs generally affirm the positive efficacy of acupuncture for simple obesity, but high-quality RCTs, particularly those comparing acupuncture with western medicines for weight loss are lacking.

Bibliometric Analysis of Traditional Medicine for Liver Tumor Based on PubMed / 世界科学技术-中医药现代化

In order to provide reference for treatment of liver tumors using traditional Chinese medicine, we analyzed the research status of liver tumor treatment with traditional Chinese Medicine based on PubMed. By the bibliography information concurrence mining system (BICOMB 2013), the literature were collected and analyzed from PubMed database from the day of establishment to 31 October 2017. CytoScape3.6.1 software was used to draw the Co-occurrence analysis chart of high-frequency subject headings and the subheadings, and SPSS17 statistical software was used to cluster the high frequency subject headings. 365 literatures were collected in total. The amount of published articles is increasing year by year. The literatures were mainly in English. From the literature indicating the author's country, we found that 70％ of the top 10 countries and regions which published the most papers were from Asia. Among them, Chinese scholars ranked first. The top 5 of the high-frequency subject headings and the subheadings were Humans, Male, Animals, Liver Neoplasms/drug therapy and Carcinoma, and Hepatocellular/drug therapy. The research focused on the following 9 aspects: metabolism of liver cells, neoplasms, liver cancer pathology, pharmacological efficacy of liver cancer, relationship between cell proliferation and apoptosis and efficacy; xenograft model antitumor assays in mice, pharmacology of antitumor Chinese herbal medicine or phytogenic drugs, the effects of dose-response relationship, cellular activity and signal transduction on drug efficacy, therapeutic uses of traditional and phytotherapy and the outcome and mortality of liver tumor. By the bibliometric analysis in the field of traditional medicine for liver tumor, we can understand the research direction and development status of this field, which can be reference for prevention and treatment of liver cancer with TCM.

Herramientas útiles y métodos de búsqueda bibliográfica en PubMed: guía paso a paso para médicos / Useful tools and methods for literature retrieval in pubmed: step-by-step guide for physicians

Developing skills to search the medical literature has potential benefits on patient care and allow physicians to better orient their efforts when answering daily clinical questions. The objective of this paper is to share useful tools for optimizing medical literature retrieval in MEDLINE using PubMed including MeSH terms, filters and connectors.

Educación continua: bases de datos biomédicas II: Medline/PubMed / Continuing education: biomedical databases II: Medline/PubMed

MEDLINE/PubMed es una de las bases de datos de bibliografía biomédica más grandes e importantes y el principal componente de PUbMed que cubre las áreas de medicina, enfermería, odontología, veterinaria, sistemas de salud y ciencias preclínicas. La interfaz de PubMed permite realizar búsquedas, no solamente en Medline, sino también en otras 35 bases de datos del NCBI (Centro Nacional para la Información Biotecnológica). Medline fue desarrollado por la Biblioteca Nacional de Medicina de los Estados Unidos (NLM), que forma parte del Instituto Nacional de Salud (NIH). En esta sexta entrega de educación continua se describen la estructura, el funcionamiento y las características de los principales componentes de Medline/PubMed que permitirán al usuario realizar una búsqueda bibliográfica más eficiente.

MEDLINE / PubMed is one of the largest and most important biomedical bibliographic databases and the main component of PUbMed that covers the areas of medicine, nursing, dentistry, veterinary, health systems and preclinical sciences. The PubMed interface allows searching not only of Medline, but also of another 35 NCBI (National Center for Biotechnology Information) databases. Medline was developed by the National Library of Medicine of the United States (NLM), which is part of the National Institute of Health (NIH). This sixth edition of continuing education describes the structure, operation and characteristics of the main components of Medline / PubMed that will allow the user to perform a more efficient bibliographic search.

Bibliometric Analysis of Metabolomics / 中国药房

OBJECTIVE:To investigate the present situation of domestic and foreign metabolomics study,and to preliminarily discuss research hotspots and development rules. METHODS:By using bibliometric methods and GoPubMed literature analysis tool,usingMetabolomicsas subject,all literatures were retrieved from PubMed database up to Jul. 31,2016. Those literatures were ranked and analyzed in respects of publication amount,countries and cities,journal sources,research topics,core authors and authors collaborative networks. UsingMetabolomicsMetabonomicsas subjects,all literatures were retrieved from Web of Science database up to Aug. 1,2016. The literatures with high citation frequency were analyzed during 2007-2016 by using the sort-ing function of citation frequency. RESULTS:A total of 15449 domestic and foreign metabolomics literatures were retrieved. The researchers of 2189 literatures came from China,and the amount of published literatures showed a rising trend. 15449 literatures were distributed in 129 countries and regions;10 countries,such as the United States,China,Britain and Germany,were the core countries,and the total number of literatures issued was 12847(83.16%). The United States held the largest share of world publi-cations(4288 literatures,27.76%),and the following was China in order(2189 literatures,14.17%). The city with the largest amount of publications was London(467 literatures),followed by Shanghai,Beijing. A total of 2168 periodicals were involved, and there were 7.1 published literatures averagely. All of the top 20 periodicals were from the United States and European countries (4377 literatures,28.33%). The first 3 subjects with the highest frequency of occurrence were metabolomics,metabolome and me-tabolism;related researches mainly focused on metabolic processes,metabolic networks and pathways,biological markers,pro-teome and genome;main research methods included spectrum analysis and magnetic resonance spectroscopy. Main 6 groups of au-thors were involved,mainly Nicholoson JK,Holmes E,Lindon J and other researchers. None of Chinese researchers had been found among the core authors and author groups. The literatures with high citation frequency mainly focused on the association of metabolism with disease,metabolomics database,metabolomics research methods and biological markers related to disease predic-tion. CONCLUSIONS:Metabolomics has aroused worldwide interest among researchers,and metabolic pathways and biological markers are the focuses in this field. Our researchers have published a large amount of literatures on metabolomics,but there are not high quality periodical carrier or enough cooperation between researchers. It is suggested to enhance the cooperation between various research institutions or grasp the frontier and hotspots of the research in this field so as to push forward the development di-versification and depth of metabolomics research in China.

Case retrieval in PubMed for improving the retrieval effectiveness of literature novelty assessors / 中华医学图书情报杂志

The retrieval of literature novelty assessment projects was divided into unlimited retrieval and limited retrieval according to the retrieval terms.The redundant retrieval mode,complicated retrieval process,poor compatibility,and lack of summary that affect the retrieval effectiveness of literature novelty assessors were analyzed.The overall retrieval ability and literature analysis ability of literature novelty assessors were put forward for improving their retrieval effectiveness.